Transmembrane signaling by the B subunit of cholera toxin: increased cytoplasmic free calcium in rat lymphocytes

@article{Dixon1987TransmembraneSB,
  title={Transmembrane signaling by the B subunit of cholera toxin: increased cytoplasmic free calcium in rat lymphocytes},
  author={Scott J. Dixon and Douglas Edward Stewart and Sergio Grinstein and Susanne Spiegel},
  journal={The Journal of Cell Biology},
  year={1987},
  volume={105},
  pages={1153 - 1161}
}
It has previously been shown that the B subunit of cholera toxin, which binds solely to the plasma membrane ganglioside GM1, stimulates the proliferation of rat thymic lymphocytes (Spiegel, S., P. H. Fishman, and R. J. Weber, 1985, Science [Wash. DC], 230:1285-1287). The purpose of this study was to identify which transmembrane signaling system(s) are activated by the B subunit of cholera toxin. We compared the effects of B subunit and concanavalin A (Con A), a potent mitogenic lectin, on a… CONTINUE READING

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