Transmembrane signaling by epidermal growth factor receptors lacking autophosphorylation sites.

@article{Decker1993TransmembraneSB,
  title={Transmembrane signaling by epidermal growth factor receptors lacking autophosphorylation sites.},
  author={Stuart J. Decker},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 13},
  pages={9176-9}
}
Mutant epidermal growth factor (EGF) receptors in which the five known tyrosine autophosphorylation sites (tyrosines 992, 1068, 1086, 1148, and 1173) were replaced with phenylalanine residues were expressed in NIH-3T3 cells (5F-EGFR) and transmembrane signaling parameters compared with cells expressing wild-type EGF receptor (WT-EGFR). Mutant and wild-type clones were chosen expressing similar numbers of receptors and Scatchard analysis of 125I-EGF binding showed high and low affinity binding… CONTINUE READING

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