Transmembrane segment 7 of human P-glycoprotein forms part of the drug-binding pocket.

@article{Loo2006TransmembraneS7,
  title={Transmembrane segment 7 of human P-glycoprotein forms part of the drug-binding pocket.},
  author={T. Y. Wings Loo and M. Claire Bartlett and David R. Clarke},
  journal={The Biochemical journal},
  year={2006},
  volume={399 2},
  pages={351-9}
}
P-gp (P-glycoprotein; ABCB1) protects us by transporting a broad range of structurally unrelated compounds out of the cell. Identifying the regions of P-gp that make up the drug-binding pocket is important for understanding the mechanism of transport. The common drug-binding pocket is at the interface between the transmembrane domains of the two homologous halves of P-gp. It has been shown in a previous study [Loo, Bartlett and Clarke (2006) Biochem. J. 396, 537-545] that the first… CONTINUE READING