Transmembrane proteoglycans control stretch-activated channels to set cytosolic calcium levels

  title={Transmembrane proteoglycans control stretch-activated channels to set cytosolic calcium levels},
  author={Sandeep Gopal and Pernille S\ogaard and Hinke A. B. Multhaupt and Csilla Pataki and Elena Okina and Xiaojie Xian and Mikael Egebjerg Pedersen and Troy Stevens and Oliver Griesbeck and Pyong Woo Park and Roger Pocock and John Robert Couchman},
  booktitle={The Journal of cell biology},
Transmembrane heparan sulfate proteoglycans regulate multiple aspects of cell behavior, but the molecular basis of their signaling is unresolved. The major family of transmembrane proteoglycans is the syndecans, present in virtually all nucleated cells, but with mostly unknown functions. Here, we show that syndecans regulate transient receptor potential canonical (TRPCs) channels to control cytosolic calcium equilibria and consequent cell behavior. In fibroblasts, ligand interactions with… CONTINUE READING
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