Transmembrane polar residues of TCR β chain are required for signal transduction

Mutagenic analyses have identified structural motifs important for TCR-mediated signaling in the antigen-binding chains, CD3 and ζ subunits of the TCR complex. In this study, we altered selected residues in the transmembrane and extracellular constant regions of the TCR β chain and expressed the mutants i n a T hybridoma line bearing endogenous receptor. We… (More)