Transmembrane polar interactions are required for signaling in the Escherichia coli sensor kinase PhoQ.

Abstract

PhoQ is the transmembrane sensor histidine kinase of the bacterial phoPQ two-component system, which detects and responds to divalent cations and to antimicrobial peptides, and can trigger virulence. Despite their ubiquitous importance in bacterial signaling, the structure and mechanism of the sensor kinases are not fully understood. In particular, the… (More)
DOI: 10.1073/pnas.1003166107

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Cite this paper

@article{Goldberg2010TransmembranePI, title={Transmembrane polar interactions are required for signaling in the Escherichia coli sensor kinase PhoQ.}, author={Shalom D Goldberg and Graham Clinthorne and Mark Goulian and William F. DeGrado}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2010}, volume={107 18}, pages={8141-6} }