Transmembrane phospholipid distribution in blood cells: control mechanisms and pathophysiological significance.

@article{Bevers1998TransmembranePD,
  title={Transmembrane phospholipid distribution in blood cells: control mechanisms and pathophysiological significance.},
  author={Edouard M. Bevers and Paul Comfurius and David W C Dekkers and Marjan Harmsma and Robert F. A. Zwaal},
  journal={Biological chemistry},
  year={1998},
  volume={379 8-9},
  pages={973-86}
}
This review deals with current concepts on the regulation and function of phospholipid asymmetry in biological membranes. This ubiquitous phenomenon is characterized by a distinctly different lipid composition between the inner and outer leaflet of the membrane bilayer. Transbilayer asymmetry is controlled by different membrane proteins that function as lipid transporters, catalyzing uni- or bi-directional transbilayer movement of lipids. Under normal conditions, an ATP-dependent protein… CONTINUE READING

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