Transmembrane passage of hydrophobic compounds through a protein channel wall

@article{Hearn2009TransmembranePO,
  title={Transmembrane passage of hydrophobic compounds through a protein channel wall},
  author={Elizabeth M. Hearn and D. R. Patel and Bryan W. Lepore and Mridhu Indic and Bert van den Berg},
  journal={Nature},
  year={2009},
  volume={458},
  pages={367-370}
}
Membrane proteins that transport hydrophobic compounds have important roles in multi-drug resistance and can cause a number of diseases, underscoring the importance of protein-mediated transport of hydrophobic compounds. Hydrophobic compounds readily partition into regular membrane lipid bilayers, and their transport through an aqueous protein channel is energetically unfavourable. Alternative transport models involving acquisition from the lipid bilayer by lateral diffusion have been proposed… CONTINUE READING