Transmembrane insertion of the Colicin Ia hydrophobic hairpin

@article{Kienker1997TransmembraneIO,
  title={Transmembrane insertion of the Colicin Ia hydrophobic hairpin},
  author={Paul K. Kienker and Xiayang Qiu and Stephen L. Slatin and Alan Finkelstein and Karen S. Jakes},
  journal={The Journal of Membrane Biology},
  year={1997},
  volume={157},
  pages={27-37}
}
Colicin Ia is a bactericidal protein that forms voltage-dependent, ion-conducting channels, both in the inner membrane of target bacteria and in planar bilayer membranes. Its amino acid sequence is rich in charged residues, except for a hydrophobic segment of 40 residues near the carboxyl terminus. In the crystal structure of colicin Ia and related colicins, this segment forms an α-helical hairpin. The hydrophobic segment is thought to be involved in the initial association of the colicin with… CONTINUE READING

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