Transmembrane helix predictions revisited.

  title={Transmembrane helix predictions revisited.},
  author={Chien Peter Chen and Andrew Kernytsky and Burkhard Rost},
  journal={Protein science : a publication of the Protein Society},
  volume={11 12},
Methods that predict membrane helices have become increasingly useful in the context of analyzing entire proteomes, as well as in everyday sequence analysis. Here, we analyzed 27 advanced and simple methods in detail. To resolve contradictions in previous works and to reevaluate transmembrane helix prediction algorithms, we introduced an analysis that distinguished between performance on redundancy-reduced high- and low-resolution data sets, established thresholds for significant differences in… CONTINUE READING
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