Transmembrane helix: simple or complex

@inproceedings{Wong2012TransmembraneHS,
  title={Transmembrane helix: simple or complex},
  author={Wing-Cheong Wong and Sebastian Maurer-Stroh and Georg Schneider and Frank Eisenhaber},
  booktitle={Nucleic Acids Research},
  year={2012}
}
Transmembrane helical segments (TMs) can be classified into two groups of so-called 'simple' and 'complex' TMs. Whereas the first group represents mere hydrophobic anchors with an overrepresentation of aliphatic hydrophobic residues that are likely attributed to convergent evolution in many cases, the complex ones embody ancestral information and tend to have structural and functional roles beyond just membrane immersion. Hence, the sequence homology concept is not applicable on simple TMs. In… CONTINUE READING

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