Transmembrane domains interactions within the membrane milieu: principles, advances and challenges.

@article{Fink2012TransmembraneDI,
  title={Transmembrane domains interactions within the membrane milieu: principles, advances and challenges.},
  author={Avner Fink and Neta Sal-Man and Doron Gerber and Yechiel Shai},
  journal={Biochimica et biophysica acta},
  year={2012},
  volume={1818 4},
  pages={974-83}
}
Protein-protein interactions within the membrane are involved in many vital cellular processes. Consequently, deficient oligomerization is associated with known diseases. The interactions can be partially or fully mediated by transmembrane domains (TMD). However, in contrast to soluble regions, our knowledge of the factors that control oligomerization and recognition between the membrane-embedded domains is very limited. Due to the unique chemical and physical properties of the membrane… CONTINUE READING

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