Transmembrane domain II of the human bile acid transporter SLC10A2 coordinates sodium translocation.

Abstract

Human apical sodium-dependent bile acid transporter (hASBT, SLC10A2) is responsible for intestinal reabsorption of bile acids and plays a key role in cholesterol homeostasis. We used a targeted and systematic approach to delineate the role of highly conserved transmembrane helix 2 on the expression and function of hASBT. Cysteine mutation significantly… (More)
DOI: 10.1074/jbc.M113.518555

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