Transmembrane asymmetry and lateral domains in biological membranes.

  title={Transmembrane asymmetry and lateral domains in biological membranes.},
  author={Philippe F. Devaux and Roger Stewart Morris},
  volume={5 4},
It is generally assumed that rafts exist in both the external and internal leaflets of the membrane, and that they overlap so that they are coupled functionally and structurally. However, the two monolayers of the plasma membrane of eukaryotic cells have different chemical compositions. This out-of-equilibrium situation is maintained by the activity of lipid translocases, which compensate for the slow spontaneous transverse diffusion of lipids. Thus rafts in the outer leaflet, corresponding to… CONTINUE READING


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