Transmembrane aromatic amino acid distribution in P-glycoprotein. A functional role in broad substrate specificity.

Abstract

Multidrug resistance (MDR) in cancer cells is associated with overexpression of P-glycoprotein (Pgp), a membrane protein which interacts with structurally diverse hydrophobic molecules of high membrane affinity. In an analysis of the molecular basis for this broad range of substrate specificity, we found that the transmembrane (TM) regions of Pgp are rich… (More)

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@article{Pawagi1994TransmembraneAA, title={Transmembrane aromatic amino acid distribution in P-glycoprotein. A functional role in broad substrate specificity.}, author={Asha B Pawagi and J Wang and Milton Silverman and Reinhart A. F. Reithmeier and Charles M. Deber}, journal={Journal of molecular biology}, year={1994}, volume={235 2}, pages={554-64} }