Transmembrane and extracellular domains of syndecan-1 have distinct functions in regulating lung epithelial migration and adhesion.

@article{Altemeier2012TransmembraneAE,
  title={Transmembrane and extracellular domains of syndecan-1 have distinct functions in regulating lung epithelial migration and adhesion.},
  author={William A Altemeier and Saundra Y. Schlesinger and Catherine A. Buell and Rena Brauer and Alan C. Rapraeger and William C. Parks and Peter Chen},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 42},
  pages={
          34927-35
        }
}
Syndecan-1 is a cell surface proteoglycan that can organize co-receptors into a multimeric complex to transduce intracellular signals. The syndecan-1 core protein has multiple domains that confer distinct cell- and tissue-specific functions. Indeed, the extracellular, transmembrane, and cytoplasmic domains have all been found to regulate specific cellular processes. Our previous work demonstrated that syndecan-1 controls lung epithelial migration and adhesion. Here, we identified the necessary… CONTINUE READING
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