Transmembrane agrin regulates filopodia in rat hippocampal neurons in culture.

  title={Transmembrane agrin regulates filopodia in rat hippocampal neurons in culture.},
  author={Seumas McCroskery and Amal Chaudhry and Lin Lin and Mathew P. Daniels},
  journal={Molecular and cellular neurosciences},
  volume={33 1},
Filopodia mediate axon guidance, neurite branching and synapse formation, but the membrane molecules that regulate neuronal filopodia in response to extracellular cues are largely unknown. The transmembrane isoform of the proteoglycan agrin, expressed predominantly in the CNS, may regulate neurite outgrowth, synapse formation and excitatory signaling. Here we demonstrate that agrin positively regulates neuronal filopodia. Over-expression of TM-agrin caused the formation of excess filopodia on… CONTINUE READING

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