Transmembrane Helix Dynamics of Bacterial Chemoreceptors Supports a Piston Model of Signalling

@inproceedings{Hall2011TransmembraneHD,
  title={Transmembrane Helix Dynamics of Bacterial Chemoreceptors Supports a Piston Model of Signalling},
  author={Benjamin A. Hall and Judith P. Armitage and Mark S. P. Sansom},
  booktitle={PLoS Computational Biology},
  year={2011}
}
Transmembrane α-helices play a key role in many receptors, transmitting a signal from one side to the other of the lipid bilayer membrane. Bacterial chemoreceptors are one of the best studied such systems, with a wealth of biophysical and mutational data indicating a key role for the TM2 helix in signalling. In particular, aromatic (Trp and Tyr) and basic (Arg) residues help to lock α-helices into a membrane. Mutants in TM2 of E. coli Tar and related chemoreceptors involving these residues… CONTINUE READING
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