Transmembrane Ca2+ gradient is essential for high anion transport activity of human erythrocytes

@article{Tu1996TransmembraneCG,
  title={Transmembrane Ca2+ gradient is essential for high anion transport activity of human erythrocytes},
  author={Y. Tu and C. Feng and H. Xu and Z. Guang and Q. Lu and F. Yang},
  journal={Bioscience Reports},
  year={1996},
  volume={16},
  pages={299-311}
}
The role of a transmembrane Ca2+ gradient in anion transport by Band 3 of human resealed erythrocyte ghosts has been studied. The results show that a transmembrane Ca2+ gradient is essential for the conformation of erythrocyte Band 3 with higher anion transport activity. The dissipation of the transmembrane Ca2+ gradient by the ionophore A23187 inhibits the anion transport activity. The extent of this inhibition approaches 90% as the Ca2+ concentration on both sides of the ghost membrane is… Expand
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