Transmembrane CEACAM1 affects integrin-dependent signaling and regulates extracellular matrix protein-specific morphology and migration of endothelial cells.

@article{Mller2005TransmembraneCA,
  title={Transmembrane CEACAM1 affects integrin-dependent signaling and regulates extracellular matrix protein-specific morphology and migration of endothelial cells.},
  author={Mario M M{\"u}ller and Bernhard B Singer and Esther Klaile and Bj{\"o}rn Obrink and Lothar Lucka},
  journal={Blood},
  year={2005},
  volume={105 10},
  pages={
          3925-34
        }
}
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1/CD66a), expressed on leukocytes, epithelia, and endothelia mediates homophilic cell adhesion. It plays an important role in cell morphogenesis and, recently, soluble CEACAM1 isoforms have been implicated in angiogenesis. In the present study, we investigated the function of long transmembrane isoform of CEACAM1 (CEACAM1-L) in cultured rat brain endothelial cells. We observed that expression of CEACAM1-L promotes network… CONTINUE READING

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