Translocator protein (TSPO) ligand-Ara-C (cytarabine) conjugates as a strategy to deliver antineoplastic drugs and to enhance drug clinical potential.

@article{Denora2010TranslocatorP,
  title={Translocator protein (TSPO) ligand-Ara-C (cytarabine) conjugates as a strategy to deliver antineoplastic drugs and to enhance drug clinical potential.},
  author={Nunzio Denora and Valentino Laquintana and Adriana Trapani and A. Lopedota and Andrea Latrofa and James M. Gallo and Giuseppe Trapani},
  journal={Molecular pharmaceutics},
  year={2010},
  volume={7 6},
  pages={2255-69}
}
The aim of this work was to evaluate TSPO ligand-Ara-C conjugation as an approach for the selective delivery of the antineoplastic agent to brain tumors as well as for overcome P-gp resistance induction observed for the majority of cytotoxic agents, enhancing the drug clinical potential. To this end, the novel N-imidazopyridinacetyl-Ara-C conjugates 3a-c… CONTINUE READING