Translocation of the MOS gene in a rare t(8;16) associated with acute myeloblastic leukemia and Down syndrome.


Cytogenetic analysis of an infant with Down syndrome with concomitant acute myelogenous leukemia revealed a unique t(8;16)(q22;q24). In situ chromosomal hybridization was used to demonstrate that the protooncogene MOS was translocated from chromosome 8 to chromosome 16. This is the first report of the transposition of MOS in association with acute leukemia. 


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