Translocation of proteins across membranes: the signal hypothesis and beyond.

@article{Blobel1979TranslocationOP,
  title={Translocation of proteins across membranes: the signal hypothesis and beyond.},
  author={G{\"u}nter Blobel and Peter J. Walter and Chen Nen Chang and B M Goldman and Ann Hart Erickson and Vishwanath R. Lingappa},
  journal={Symposia of the Society for Experimental Biology},
  year={1979},
  volume={33},
  pages={9-36}
}
Proteins are translocated across membranes either coupled to translation (co-translationally) or after translation (post-translationally). The information for both modes of translocation is encoded in the protein in the form of a short-lived sequence extension (signal sequence). Additional information resides in the ribosome in the case of co-translational translocation, which proceeds via a ribosome--membrane junction. Translocation is mediated by specific receptors (ribosome and/or signal… CONTINUE READING