Translocation of p21rac2 from cytosol to plasma membrane is neither necessary nor sufficient for neutrophil NADPH oxidase activity.

@article{Philips1995TranslocationOP,
  title={Translocation of p21rac2 from cytosol to plasma membrane is neither necessary nor sufficient for neutrophil NADPH oxidase activity.},
  author={Mark R Philips and Aleksander S Feoktistov and Michael H. Pillinger and Steven B. Abramson},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 19},
  pages={11514-21}
}
Activation of the membrane-associated NADPH oxidase of neutrophils requires several cytosolic factors including p47phox, p67phox and p21rac2. We compared NADPH oxidase activity with the membrane translocation of p47phox, p67phox, and p21rac2. In a cell-free system, GTP gamma S stimulated translocation of p47phox and p67phox to the plasma membrane only in the presence of arachidonate, and this translocation correlated with NADPH oxidase activity of the reisolated plasma membranes (R = 0.94 and 0… CONTINUE READING

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