Translocation of glutamate transporter subtype excitatory amino acid carrier 1 protein in kainic acid-induced rat epilepsy.

@article{Furuta2003TranslocationOG,
  title={Translocation of glutamate transporter subtype excitatory amino acid carrier 1 protein in kainic acid-induced rat epilepsy.},
  author={Akiko Furuta and Mami Noda and Satoshi O. Suzuki and Yoshinobu Goto and Yoshiko Kanahori and Jeffrey D. Rothstein and Toru Iwaki},
  journal={The American journal of pathology},
  year={2003},
  volume={163 2},
  pages={
          779-87
        }
}

Figures from this paper

EAAC1 Glutamate Transporter Expression in the Rat Lithium-Pilocarpine Model of Temporal Lobe Epilepsy

TLDR
The temporal expression of the neuronal glutamate transporter (EAAC1) in the lithium-pilocarpine rat model of temporal lobe epilepsy was examined and the overexpression of EAAC1 occurred mainly in structures prone to develop Fluoro-Jade-B-positive degenerating neurons.

Excitatory Amino Acid Transporters in Physiology and Disorders of the Central Nervous System

TLDR
The studies in cellular and animal models, as well as in humans, that highlight the roles of EAATs in the pathogenesis of these devastating disorders are reviewed.

Reticulon RTN2B Regulates Trafficking and Function of Neuronal Glutamate Transporter EAAC1*

TLDR
It is shown that RTN2B, a member of the reticulon protein family that mainly localizes in the ER and ER exit sites interacts with EAAC1 and GTRAP3-18, and functions as a positive regulator in the delivery ofEAAC1 from the ER to the cell surface.

The neuronal excitatory amino acid transporter EAAC1/EAAT3: does it represent a major actor at the brain excitatory synapse?

TLDR
Interestingly, EAAC1/EAAT3 activity/expression was shown to be highly regulated by neuronal activity as well as by intracellular signalling pathways involving primarily α protein kinase C (αPKC) and phosphatidylinositol‐3‐kinase (PI3K).

Syntaxin 1A promotes the endocytic sorting of EAAC1 leading to inhibition of glutamate transport

TLDR
It is demonstrated that EAAC1 undergoes internalization through the clathrin-mediated pathway and further shown that syntaxin 1A, a key molecule in synaptic exocytosis, potentiatesEAAC1 internalization, thus leading to the functional inhibition of EAAC 1.

Unique anti‐apoptotic activity of EAAC1 in injured motor neurons

TLDR
A unique ‘rescue’ function of EAAC1 is revealed, which is independent of removal of extracellular glutamate, which functions in rescuing PC12 cells and motor neurons from NGF deprivation and nerve injury, respectively.

References

SHOWING 1-10 OF 43 REFERENCES

Changes in expression of neuronal and glial glutamate transporters in rat hippocampus following kainate-induced seizure activity.

Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18

TLDR
These studies show that glutamate transport proteins can be regulated potently and that GTRAP can modulate the transport functions ascribed to EAAC1, and may be important in regulating the metabolic function ofEAAC1.

EAAC 1 , a High-affinity Glutamate Transporter , is Localized to Astrocytes and Gabaergic Neurons besides Pyramidal Cells in the Rat Cerebral Cortex

TLDR
The localization of EAAC1 may explain the pathological symptoms that follow EAAC knockout (seizures and mild toxicity), as seizures could be due to the loss ofEAAC1-mediated fine regulation of neuronal excitability at axodendritic and axospinous synapses, whereas the mild toxicity may be related to the functional inactivation of astrocytic EAAC 1.

EAAC1, a high-affinity glutamate tranporter, is localized to astrocytes and gabaergic neurons besides pyramidal cells in the rat cerebral cortex.

TLDR
The localization of EAAC1 may explain the pathological symptoms that follow EAAC knockout (seizures and mild toxicity), as seizures could be due to the loss ofEAAC1-mediated fine regulation of neuronal excitability at axodendritic and axospinous synapses, whereas the mild toxicity may be related to the functional inactivation of astrocytic EAAC 1.

Altered expressions of glutamate transporter subtypes in rat model of neonatal cerebral hypoxia-ischemia.

Multiple Signaling Pathways Regulate Cell Surface Expression and Activity of the Excitatory Amino Acid Carrier 1 Subtype of Glu Transporter in C6 Glioma

TLDR
The studies suggest that the trafficking of the neuronal glutamate transporter EAAC1 is regulated by two independent signaling pathways and also may suggest a novel endogenous protective mechanism to limit glutamate-induced excitotoxicity.

Alterations in Glutamate Transporter Protein Levels in Kindling‐Induced Epilepsy

TLDR
Modulation of high‐affinity glutamate uptake is a potential mechanism responsible for the elevated levels observed with seizures and changes in transporter levels could contribute to the changes in glutamate levels seen with kindling.

Altered Expression of the Glutamate Transporter EAAC1 in Neurons and Immature Oligodendrocytes after Transient Forebrain Ischemia

  • M. GottliebM. DomercqC. Matute
  • Biology
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2000
TLDR
Enhanced expression of EAAC1 may be an adaptive response to increased levels of extracellular glutamate during ischemia, and is located in oligodendroglial progenitor cells in subcortical white matter.

Localization of neuronal and glial glutamate transporters