Translocation of flexible polymersomes across pores at the nanoscale.

@article{Pegoraro2014TranslocationOF,
  title={Translocation of flexible polymersomes across pores at the nanoscale.},
  author={Carla Pegoraro and Denis Cecchin and Jeppe Nejsum Madsen and Nicholas J. H. Warren and Steven P Armes and Sheila MacNeil and Andrew L Lewis and Giuseppe Battaglia},
  journal={Biomaterials science},
  year={2014},
  volume={2 5},
  pages={
          680-92
        }
}
Hierarchical biological systems such as tissues and organs are often characterised by highly crowded and packed environments with nanoscopic interconnections between them. Engineering nanovectors that can penetrate and diffuse across these is critical to ensure enhanced delivery and targeting. Here we demonstrate that flexible polymeric vesicles, known as polymersomes, enable the translocation of large macromolecules across both synthetic and biological porous systems. We compare the… CONTINUE READING

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