Translocation of caveolin regulates stretch-induced ERK activity in vascular smooth muscle cells.

@article{Kawabe2004TranslocationOC,
  title={Translocation of caveolin regulates stretch-induced ERK activity in vascular smooth muscle cells.},
  author={Jun-Ichi Kawabe and Satoshi Okumura and Ming-Chih Lee and Junichi Sadoshima and Yoshihiro Ishikawa},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2004},
  volume={286 5},
  pages={H1845-52}
}
Mechanical stress contributes to vascular disease related to hypertension. Activation of ERK is key to mediating cellular proliferation and vascular remodeling in response to stretch stress. However, the mechanism by which stretch mediates ERK activation in the vascular tissue is still unclear. Caveolin, a major component of a flasklike invaginated caveolae, acts as an adaptor protein for an integrin-mediated signaling pathway. We found that cyclic stretch transiently induced translocation of… CONTINUE READING