Translocation of a lysosomal enzyme across the microsomal membrane requires signal recognition particle.

Abstract

Signal recognition particle (SRP), an 11S ribonucleoprotein (Walter and Blobel (1982) Nature 299, 691-698), is required for translocation of secretory proteins across microsomal membranes (Walter and Blobel (1980) Proc. Natl. Acad. Sci. USA 77, 7112-7116) and for asymmetric integration into microsomal membranes of a transmembrane protein (Anderson et al., (1982) J. Cell Biol. 93, 501-506). We demonstrate here that SRP is also required for translocation of the lysosomal protease cathepsin D across microsomal membranes.

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Cite this paper

@article{Erickson1983TranslocationOA, title={Translocation of a lysosomal enzyme across the microsomal membrane requires signal recognition particle.}, author={Ann Hart Erickson and Peter Walter and G{\"{u}nter Blobel}, journal={Biochemical and biophysical research communications}, year={1983}, volume={115 1}, pages={275-80} }