Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteins

@article{Fincham1996TranslocationOS,
  title={Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteins},
  author={Valerie J. Fincham and Mehtat Unlu and Valerie G Brunton and John D. Pitts and J. A. Wyke and Margaret C Frame},
  journal={The Journal of Cell Biology},
  year={1996},
  volume={135},
  pages={1551 - 1564}
}
We have isolated Swiss 3T3 subclones that are resistant to the mitogenic and morphological transforming effects of v-Src as a consequence of aberrant translocation of the oncoprotein under low serum conditions. In chicken embryo and NIH 3T3 fibroblasts under similar conditions, v-Src rapidly translocates from the perinuclear region to the focal adhesions upon activation of the tyrosine kinase, resulting in downstream activation of activator protein-1 and mitogen-activated protein kinase, which… CONTINUE READING

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Requirement for phosphoinositide 3 - kinase in insulin - stimulated GLUT 4 translocation in 3 T 3L 1 adipocytes

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