Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage.

@article{Kharbanda2000TranslocationOS,
  title={Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage.},
  author={Surender Kharbanda and Satya Saxena and Ken-ichi Yoshida and Pramod Pandey and Masao Kaneki and Qin Wang and Kim Cheng and Y. N. Chen and Amanda Campbell and Thangirala Sudha and Zengqiang Yuan and Jagat S. Narula and Ralph Weichselbaum and Carlo M. Nalin and Donald Kufe},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 1},
  pages={322-7}
}
Activation of the stress-activated protein kinase (SAPK/JNK) by genotoxic agents is necessary for induction of apoptosis. We report here that ionizing radiation ionizing radiation exposure induces translocation of SAPK to mitochondria and association of SAPK with the anti-apoptotic Bcl-x(L) protein. SAPK phosphorylates Bcl-x(L) on threonine 47 (Thr-47) and threonine 115 (Thr-115) in vitro and in vivo. In contrast to wild-type Bcl-x(L), a mutant Bcl-x(L) with the two threonines substituted by… CONTINUE READING
Highly Influential
This paper has highly influenced 16 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 142 extracted citations

JNK regulates FoxO-dependent autophagy in neurons.

Genes & development • 2011
View 10 Excerpts
Highly Influenced

Photodynamic therapy with the phthalocyanine photosensitizer Pc 4 of SW480 human colon cancer xenografts in athymic mice.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2000
View 4 Excerpts
Highly Influenced

Withaferin A activates stress signalling proteins in high risk acute lymphoblastic leukemia.

International journal of clinical and experimental pathology • 2015
View 6 Excerpts
Highly Influenced

Protective effect of hypoxia on bisphosphonate‑related bone cell damage.

Molecular medicine reports • 2010
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…