Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage.

  title={Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage.},
  author={Surender Kharbanda and Satya Saxena and Ken-ichi Yoshida and Pramod Pandey and Masao Kaneki and Qin Wang and Kim Cheng and Y. N. Chen and Amanda Campbell and Thangirala Sudha and Zengqiang Yuan and Jagat S. Narula and Ralph Weichselbaum and Carlo M. Nalin and Donald Kufe},
  journal={The Journal of biological chemistry},
  volume={275 1},
Activation of the stress-activated protein kinase (SAPK/JNK) by genotoxic agents is necessary for induction of apoptosis. We report here that ionizing radiation ionizing radiation exposure induces translocation of SAPK to mitochondria and association of SAPK with the anti-apoptotic Bcl-x(L) protein. SAPK phosphorylates Bcl-x(L) on threonine 47 (Thr-47) and threonine 115 (Thr-115) in vitro and in vivo. In contrast to wild-type Bcl-x(L), a mutant Bcl-x(L) with the two threonines substituted by… CONTINUE READING
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