Translocation of PKG1α acts on TRPV4-C1 heteromeric channels to inhibit endothelial Ca2+ entry

@inproceedings{Zhang2016TranslocationOP,
  title={Translocation of PKG1α acts on TRPV4-C1 heteromeric channels to inhibit endothelial Ca2+ entry},
  author={Peng Zhang and Ai-qin Mao and Chun-yuan Sun and Xiao-Dong Zhang and Qiong-xi Pan and Dan-tong Yang and Jian Jin and Chun-lei Tang and Zhen-yu Yang and Xiao-qiang Yao and Xiao-Jie Lu and Xin Ma},
  booktitle={Acta Pharmacologica Sinica},
  year={2016}
}
Aim:TRPV4-C1 heteromeric channels contribute to store-operated Ca2+ entry in vascular endothelial cells. However, the negative regulation of these channels is not fully understood. This study was conducted to investigate the inhibitory effect of PKG1α on TRPV4-C1 heteromeric channels.Methods:Immuno-fluorescence resonance energy transfer (FRET) was used to explore the spatial proximity of PKG1α and TRPC1. Phosphorylation of endogenous TRPC1 was tested by phosphorylation assay. [Ca2+]i transients… CONTINUE READING
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