Translocation of Inhaled Ultrafine Manganese Oxide Particles to the Central Nervous System

Abstract

BACKGROUND Studies in monkeys with intranasally instilled gold ultrafine particles (UFPs; <100 nm) and in rats with inhaled carbon UFPs suggested that solid UFPs deposited in the nose travel along the olfactory nerve to the olfactory bulb. METHODS To determine if olfactory translocation occurs for other solid metal UFPs and assess potential health effects… (More)

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