Translocation of GluR1-containing AMPA receptors to a spinal nociceptive synapse during acute noxious stimulation.


Potentiation of spinal nociceptive transmission by synaptic delivery of AMPA receptors, via an NMDA receptor- and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)-dependent pathway, has been proposed to underlie certain forms of hyperalgesia, the enhanced pain sensitivity that may accompany inflammation or tissue injury. However, the specific synaptic… (More)
DOI: 10.1523/JNEUROSCI.5749-07.2008


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