Translocation-Capture Sequencing Reveals the Extent and Nature of Chromosomal Rearrangements in B Lymphocytes

@article{Klein2011TranslocationCaptureSR,
  title={Translocation-Capture Sequencing Reveals the Extent and Nature of Chromosomal Rearrangements in B Lymphocytes},
  author={Isaac A Klein and Wolfgang Resch and Mila Jankovic and Thiago Y. K. Oliveira and Arito Yamane and Hirotaka Nakahashi and Michela Di Virgilio and Anne Bothmer and Andr{\'e} Nussenzweig and Davide F Robbiani and Rafael Casellas and Michel C. Nussenzweig},
  journal={Cell},
  year={2011},
  volume={147},
  pages={95-106}
}
Chromosomal rearrangements, including translocations, require formation and joining of DNA double strand breaks (DSBs). These events disrupt the integrity of the genome and are frequently involved in producing leukemias, lymphomas and sarcomas. Despite the importance of these events, current understanding of their genesis is limited. To examine the origins of chromosomal rearrangements we developed Translocation Capture Sequencing (TC-Seq), a method to document chromosomal rearrangements genome… CONTINUE READING
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