Translocation (4;11)(p12;q23) with rearrangement of FRYL and MLL in therapy-related acute myeloid leukemia.

@article{Sait2007TranslocationW,
  title={Translocation (4;11)(p12;q23) with rearrangement of FRYL and MLL in therapy-related acute myeloid leukemia.},
  author={Sheila N. J. Sait and Melinda A Claydon and Jeffrey M. Conroy and Norma J. Nowak and Maurice Barcos and Maria R. Baer},
  journal={Cancer genetics and cytogenetics},
  year={2007},
  volume={177 2},
  pages={143-6}
}
Reciprocal chromosomal translocations involving the MLL gene at chromosome region 11q23 are recurring cytogenetic abnormalities in both de novo and therapy-related acute myeloid leukemia (AML) and in acute lymphoblastic leukemia. We report a t(4;11)(p12;q23) with rearrangement of MLL and FRYL (also known as AF4p12), a human homolog to the furry gene of Drosophila, in an adult patient with therapy-related AML after fludarabine and rituximab therapy for small lymphocytic lymphoma and radiation… CONTINUE READING