Translocating proline-rich peptides from the antimicrobial peptide bactenecin 7.

@article{Sadler2002TranslocatingPP,
  title={Translocating proline-rich peptides from the antimicrobial peptide bactenecin 7.},
  author={Kristen Sadler and Khee Dong Eom and Jinlong Yang and Yoana N. Dimitrova and James P Tam},
  journal={Biochemistry},
  year={2002},
  volume={41 48},
  pages={14150-7}
}
The intracellular delivery of most peptides, proteins, and nucleotides to the cytoplasm and nucleus is impeded by the cell membrane. To allow simplified, noninvasive delivery of attached cargo, cell-permeant peptides that are either highly cationic or hydrophobic have been utilized. Because cell-permeable peptides share half of the structural features of antimicrobial peptides containing clusters of charge and hydrophobic residues, we have explored antimicrobial peptides as templates for… CONTINUE READING