Translin-associated factor X is post-transcriptionally regulated by its partner protein TB-RBP, and both are essential for normal cell proliferation.

@article{Yang2004TranslinassociatedFX,
  title={Translin-associated factor X is post-transcriptionally regulated by its partner protein TB-RBP, and both are essential for normal cell proliferation.},
  author={Shicheng Yang and Yoon Shin Cho and Vargheese M Chennathukuzhi and Lara A. Underkoffler and Kathleen Loomes and Norman B. Hecht},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 13},
  pages={12605-14}
}
To determine the functions of the DNA/RNA-binding protein TB-RBP in somatic cells, we examined cultured primary mouse embryonic fibroblasts (MEFs) derived from TB-RBP-deficient mice. The TB-RBP-deficient MEFs exhibit a reduced growth rate compared with MEFs from littermates. Reintroduction of TB-RBP remedies this defect. A partner protein of TB-RBP, Translin-associated factor X (TRAX), was absent in TB-RBP-deficient MEFs, despite normal TRAX mRNA levels. TRAX is dependent upon the presence of… CONTINUE READING

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