Translesion synthesis across 1,N2-ethenoguanine by human DNA polymerases.


1,N(2)-Etheno(epsilon)guanine (epsilon) is formed in DNA as a result of exposure to certain vinyl monomers (e.g., vinyl chloride) or from lipid peroxidation. This lesion has been shown to be mutagenic in bacteria and mammalian cells. 1,N(2)-epsilon-G has been shown to block several model replicative DNA polymerases (pols), with limited bypass. Recently, an… (More)


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@article{Choi2006TranslesionSA, title={Translesion synthesis across 1,N2-ethenoguanine by human DNA polymerases.}, author={Jeong-Yun Choi and Hong Zang and K. Juliet Catherine Angel and Ivan D. Kozekov and Angela K. Goodenough and Carmelo J. Rizzo and F Peter Guengerich}, journal={Chemical research in toxicology}, year={2006}, volume={19 6}, pages={879-86} }