Translesion DNA polymerases remodel the replisome and alter the speed of the replicative helicase.

@article{Indiani2009TranslesionDP,
  title={Translesion DNA polymerases remodel the replisome and alter the speed of the replicative helicase.},
  author={Chiara Indiani and Lance D Langston and Olga Yurieva and Myron F. Goodman and Michael E O'Donnell},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 15},
  pages={6031-8}
}
All cells contain specialized translesion DNA polymerases that replicate past sites of DNA damage. We find that Escherichia coli translesion DNA polymerase II (Pol II) and polymerase IV (Pol IV) function with DnaB helicase and regulate its rate of unwinding, slowing it to as little as 1 bp/s. Furthermore, Pol II and Pol IV freely exchange with the polymerase III (Pol III) replicase on the beta-clamp and function with DnaB helicase to form alternative replisomes, even before Pol III stalls at a… CONTINUE READING

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