Translationally controlled tumor protein is a novel biological target for neurofibromatosis type 1-associated tumors.

@article{Kobayashi2014TranslationallyCT,
  title={Translationally controlled tumor protein is a novel biological target for neurofibromatosis type 1-associated tumors.},
  author={Daiki Kobayashi and Mio Hirayama and Yoshihiro Komohara and Souhei Mizuguchi and Masayo Wilson Morifuji and Hironobu Ihn and Motohiro Takeya and Akira Kuramochi and Norie Araki},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 38},
  pages={26314-26}
}
Neurofibromatosis type 1 (NF1) is an autosomal dominant disease that predisposes individuals to develop benign neurofibromas and malignant peripheral nerve sheath tumors (MPNSTs). Due to the lack of information on the molecular mechanism of NF1-associated tumor pathogenesis or biomarkers/therapeutic targets, an effective treatment for NF1 tumors has not been established. In this study, the novel NF1-associated protein, translationally controlled tumor protein (TCTP), was identified by… CONTINUE READING

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