Translationally controlled tumor protein interacts with nucleophosmin during mitosis in ES cells.

@article{Johansson2010TranslationallyCT,
  title={Translationally controlled tumor protein interacts with nucleophosmin during mitosis in ES cells.},
  author={Helena Johansson and Dzeneta Vizlin-Hodzic and Tomas Simonsson and Stina Simonsson},
  journal={Cell cycle},
  year={2010},
  volume={9 11},
  pages={2160-9}
}
Somatic cell nuclear transfers and the generation of induced pluripotent stem cells provide potential routes towards non-immunogenic cell replacement therapies. Translationally controlled tumor protein (Tpt1) was recently suggested to regulate cellular pluripotency. Here we explore functions of Tpt1 in mouse embryonic stem (ES) cells. We find that Tpt1 is present in the nucleus and cytoplasm of ES cells, and that specifically nuclear Tpt1 decreases upon cell differentiation. We also find that… CONTINUE READING
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