Translational upregulation of folate receptors is mediated by homocysteine via RNA-heterogeneous nuclear ribonucleoprotein E1 interactions.

@article{Antony2004TranslationalUO,
  title={Translational upregulation of folate receptors is mediated by homocysteine via RNA-heterogeneous nuclear ribonucleoprotein E1 interactions.},
  author={A. Antony and Ying-Sheng Tang and R. A. Khan and Mangatt P Biju and X. Xiao and Q. Li and Xin-Lai Sun and H. Jayaram and S. Stabler},
  journal={The Journal of clinical investigation},
  year={2004},
  volume={113 2},
  pages={
          285-301
        }
}
Cellular acquisition of folate is mediated by folate receptors (FRs) in many malignant and normal human cells. Although FRs are upregulated in folate deficiency and downregulated following folate repletion, the mechanistic basis for this relationship is unclear. Previously we demonstrated that interaction of an 18-base cis-element in the 5'-untranslated region of FR mRNA and a cystolic trans-factor (heterogeneous nuclear ribonucleoprotein E1 [hnRNP E1]) is critical for FR synthesis. However… Expand
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