Translational toxicology in setting occupational exposure limits for dusts and hazard classification – a critical evaluation of a recent approach to translate dust overload findings from rats to humans

@inproceedings{Morfeld2015TranslationalTI,
  title={Translational toxicology in setting occupational exposure limits for dusts and hazard classification – a critical evaluation of a recent approach to translate dust overload findings from rats to humans},
  author={Peter Morfeld and Joachim Bruch and Len S Levy and Yufanyi Ngiewih and Ishrat S. Chaudhuri and Henry J. Muranko and Ross Myerson and Robert J. McCunney},
  booktitle={Particle and Fibre Toxicology},
  year={2015}
}
We analyze the scientific basis and methodology used by the German MAK Commission in their recommendations for exposure limits and carcinogen classification of “granular biopersistent particles without known specific toxicity” (GBS). These recommendations are under review at the European Union level. We examine the scientific assumptions in an attempt to reproduce the results. MAK’s human equivalent concentrations (HECs) are based on a particle mass and on a volumetric model in which results… CONTINUE READING
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