Translational research on esophageal adenocarcinoma: from cell line to clinic.

Abstract

Human esophageal adenocarcinoma (EAC) cell lines have made a substantial contribution to elucidating mechanisms of carcinogenesis and drug discovery. Model research on EAC relies almost entirely on a relatively small set of established tumor cell lines because appropriate animal models are lacking. Nowadays, more than 20% of all fundamental translational… (More)
DOI: 10.1111/dote.12095

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