Translational research in medication development for nicotine dependence

@article{Lerman2007TranslationalRI,
  title={Translational research in medication development for nicotine dependence},
  author={Caryn Lerman and Mark G Lesage and Kenneth A Perkins and Stephanie S O'Malley and Steven J. Siegel and Neal L Benowitz and William A. Corrigall},
  journal={Nature Reviews Drug Discovery},
  year={2007},
  volume={6},
  pages={746-762}
}
A major obstacle to the development of medications for nicotine dependence is the lack of animal and human laboratory models with sufficient predictive clinical validity to support the translation of knowledge from laboratory studies to clinical research. This Review describes the animal and human laboratory paradigms commonly used to investigate the pathophysiology of nicotine dependence, and proposes how their predictive validity might be determined and improved, thereby enhancing the… CONTINUE READING

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