Translational repression precedes and is required for ZAP-mediated mRNA decay.

@article{Zhu2012TranslationalRP,
  title={Translational repression precedes and is required for ZAP-mediated mRNA decay.},
  author={Yiping Zhu and Xinlu Wang and Stephen P Goff and Guangxia Gao},
  journal={The EMBO journal},
  year={2012},
  volume={31 21},
  pages={4236-46}
}
Translational repression and mRNA degradation are two major mechanisms for post-transcriptional regulation of gene expression. The detailed relationship between these two processes is not yet well established. Zinc-finger antiviral protein (ZAP) inhibits the replication of certain viruses, including human immunodeficiency virus 1, by binding directly to specific viral mRNAs and recruiting cellular mRNA degradation machinery to degrade the target mRNA. Here, we report that ZAP also inhibits the… CONTINUE READING

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