Translational repression of MCL-1 couples stress-induced eIF2 alpha phosphorylation to mitochondrial apoptosis initiation.

@article{Fritsch2007TranslationalRO,
  title={Translational repression of MCL-1 couples stress-induced eIF2 alpha phosphorylation to mitochondrial apoptosis initiation.},
  author={Ralph M Fritsch and G. R. Eugenia Schneider and Dieter Saur and Melanie Scheibel and Roland M Schmid},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 31},
  pages={22551-62}
}
The integrated stress response (ISR) integrates a broad range of environmental and endogenous stress signals to the phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 (eIF2 alpha). Although intense or prolonged activation of this pathway is known to induce apoptosis, the molecular mechanisms coupling stress-induced eIF2 alpha phosphorylation to the cell death machinery have remained incompletely understood. In this study, we characterized apoptosis initiation in… CONTINUE READING