Translational repression by a novel partner of human poly(A) binding protein, Paip2.

@article{Khaleghpour2001TranslationalRB,
  title={Translational repression by a novel partner of human poly(A) binding protein, Paip2.},
  author={Kianoush Khaleghpour and Yuri V. Svitkin and Andrew W. B. Craig and Christine Demaria and Rahul C. Deo and Stephen K. Burley and Nahum Sonenberg},
  journal={Molecular cell},
  year={2001},
  volume={7 1},
  pages={205-16}
}
The eukaryotic mRNA 3' poly(A) tail acts synergistically with the 5' cap structure to enhance translation. This effect is mediated by a bridging complex, composed of the poly(A) binding protein (PABP), eIF4G, and the cap binding protein, eIF4E. PABP-interacting protein 1 (Paip1) is another factor that interacts with PABP to coactivate translation. Here, we describe a novel human PABP-interacting protein (Paip2), which acts as a repressor of translation both in vitro and in vivo. Paip2… CONTINUE READING
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