Translational regulation of the Escherichia coli stress factor RpoS: a role for SsrA and Lon.

@article{Ranquet2007TranslationalRO,
  title={Translational regulation of the Escherichia coli stress factor RpoS: a role for SsrA and Lon.},
  author={Caroline Ranquet and Susan Gottesman},
  journal={Journal of bacteriology},
  year={2007},
  volume={189 13},
  pages={4872-9}
}
Escherichia coli cell viability during starvation is strongly dependent on the expression of the rpoS gene, encoding the RpoS sigma subunit of RNA polymerase. RpoS abundance has been reported to be regulated at many levels, including transcription initiation, translation, and protein stability. The regulatory RNA SsrA (or tmRNA) has both tRNA and mRNA activities, relieving ribosome stalling and cotranslationally tagging proteins. We report here that SsrA is needed for the correct high-level… CONTINUE READING

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