Translational regulation of TRAIL sensitivity.

  title={Translational regulation of TRAIL sensitivity.},
  author={Amith Panner and Andrew T. Parsa and Russell O. Pieper},
  journal={Cell cycle},
  volume={5 2},
TNF-related apoptosis-inducing ligand (TRAIL) is a peptide that induces apoptosis to varying degrees in tumor cells. While TRAIL sensitivity in tumors has been linked to c-myc- and MEK/Erk-induced enhancement of caspase activation, our recent study identified a third input controlling TRAIL sensitivity, namely the Akt-mTOR pathway. We showed that instead of enhancing TRAIL sensitivity, Akt expression, acting through mTOR and the mTOR targets S6 kinase and eIF-4E, selectively enhances… CONTINUE READING

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